BIOGRAPHICAL SKETCH

 

Maisam Mitalipova

E-mail: mitalipova@hotmail.com

 

EDUCATION

 

 

INSTITUTION AND LOCATION

 

DEGREE

(if applicable)

 

YEAR(s)

 

FIELD OF STUDY

 

Timiryazev Agricultural Academy, Moscow, Russia           

 

Department of Biothechnology of National Research institute of Animal Husbandry, Laboratory of Developmental Biology, Russian Agricultural Academy.               

Dubrovitsy, Moscow  Region, Russia   

 

University of Wisconsin-Madison Department of Animal Science, Dr. Neal First Laboratory, Madison, Wisconsin                    

 

B.S.

 M.S.

 

 

PhD

 

 

 

Postdoctoral Training

and Research Scientist

 

 

1983-1985

1985-1988

 

 

1991-1995

 

 

 

1996-2001

 

 

Embryology Genetics and Physiology

 

Embryology, Genetics, Reproductive Physiology

 

 

PROFILE

 

Devoted research scientist focusing on isolation, maintenance and differentiation of human embryonic stem cells, primarily for Parkinson's disease therapy.

Proven history of established cloning skills, including using bovine somatic cells for cloning to live birth. Successful grant applications for somatic cell cloning and embryonic stem cells research. 

Interested in teaching partly from the experience of advising graduate students and post doctoral fellows in their research projects, and also from previous teaching experience.

Fluent in 3 languages: Russian, English, and Uighur (Turkish)

 

 

1995-1996                

Senior Research Scientist ,

Laboratory of Developmental ,Genetics,

National Research Center for Medical Genetics, Russian Academy of Medical, Sciences, Moscow, Russia       

           

1996-2001                 

Associate Researcher                            

University of Wisconsin-Madison, Animal Sciences  Department

 

2001-present              

Research Scientist                                 

Stem Cell Group,

BresaGen., Inc. Athens, GA

 

2003-present             

Research Scientist                                   

University of Georgia, Athens

Animal and Dairy Sciences

 

HONORS:  SABIT (Specialized American Internship Training) fellowship for work done at Advanced Breeder Services, WI (1993-1994). 

 

TEACHING EXPERIENCE: While at the University of Wisconsin-Madison I was a teaching assistant for Embryology and Gametogenesis and Reproductive Physiology course taught by Dr. Neal First. Also, I have taught cloning and ES cell techniques to graduate students and a number of visiting scientists from all over the world at Dr. Neal First’s lab. I was the first scientist employed in the US division of Bresagen, Inc. After successfully isolating human ES cells, I began teaching other scientists and research assistants employed by Bresagen, along with Dr. Steve Stice’s graduate and post doc students, to maintain and differentiate human ES cells.

 

Invited Speaker

 

Lecture at the Department of Biochemistry, University of Adelaide, Australia, August 2001

Lecture at the meeting “Current Status and Perpectives in Cloning and Related Studies”, Tsukuba, Japan, October, 2001

Lecture at the University of Kobe, Japan, October, 2001

Lecture at the University of Georgia, Athens, March 2001

Senior editor of embryonic stem cells section for the International Embryo Transfer Society, 2003

Lecture at the Department of Animal Science, University of Georgia, Athens, November, 2002

 

SOCIETY MEMBERSHIPS:

American Society of Cell Biology, Russian Association of Cell Culture, Society for the Study of Reproduction, International Embryo Transfer Society

 

Professional Skills:   

Cell culture, karyotyping, establishment of embryonic stem (ES) cells from different species (bovine, mouse and human), gene transformation of cells and embryos, IVM, IVF of bovine embryos, micromanipulation techniques, nuclear transfer, immunocytochemistry, immunohistochemistry techniques, PCR analysis, RNA and DNA isolation.

 

 

PUBLICATIONS — Selected Journal Articles

 

 

Schulz TC, Palmarini GM, Noggle S, Weiler DA, Mitalipova MM, Condie BG.  Directed neuronal differentiation of human embryonic stem cells.
BMC Neurosci. 2003 Oct 22;4(1):27.

 

Mitalipova MM, Wininger D, Lyons I, Robbins A, Stice S. Human pluripotent embryonic stem cell lines derived from discarded embryos. Stem Cells, 2003; 21(5):521-6

 

Calhoun JD, Lambert NA, Mitalipova MM, Noggle SA, Lyons I, Condie BG, Stice SL. Differentiation of resus embryonic stem cells to neural progenitors and neurons. BBRC,2003, Vol.306: 191-197

 

Mitalipova MM, Beyhan Z., First LN. Pluripotency of bovine embryonic stem cells derived from precompacting embryos. Cloning, 2001, Vol 3, No.2, pp 59-67.

 

Dominko T., Mitalipova M., Haley B., Beyhan Z., Memili E., Mcqucik B., and First N. Bovine oocyte cytoplasm supports development of embryos produced by nuclear transfer of somatic cell nuclei from various mammalian species. Biology of Reproduction, 1999, Vol.60, pp. 1496-1502

 

First L. N., Mitalipova M., Kent-First M. Reproductive technologies and transgenics.  Book chapter in “The genetics of cattle”, 1999, pp.411-436.  CABI publishing, UK.

 

Mitalipov S.M., Mitalipova M.M., Ivanov V.I. The effect of long-time culture on the developmental potency in vitro and in vivo of mice embryonic stem (ES) cells. Ontogenez (Russian). 1994.  V. 25, N. 6. P. 19-27.

 

Mitalipov S.M., Mitalipova M.M. The effect of host blastocyst's genotype on the efficiency of chimera production by mouse ES cells. Genetics (Russian). 1994.  V.30 (supplement). P.101.

 

 

Patents and pending patents

 

Mitalipova MM., Dominko T., First NL  1999. Trans-Species Nuclear Transfer. University of Wisconsin - Madison U.S. Patent #09/463,276

Invented the method of nuclear transfer by using bovine oocyte cytoplasm as universal recipient to reprogram somatic donor nuclei from four different mammalian species.

 

Mitalipova MM., Beyhan Z., First NL. 2001 Bovine nuclear transfer using somatic cells. University of Wisconsin-Madison.

 

Mitalipova MM., Lyons I. 2002 Alternative composition and methods for the culture of stem cells. 2001. BresaGen, Inc.US Patent Application No. 60/310,355

Developed methods and culture conditions for isolation and maintenance of human pluripotent embryonic stem cells on human feeders.

 

Mitalipova MM., Lyons I., Robins A. 2002. Compositions and methods for primate neural cell production. BresaGen, Inc. US Patent Application No. 60/364,381

Invented methods and culture conditions for isolation and maintenance of primate and human neural progenitors from embryonic stem cells that can be specifically differentiated to dopaminergic neurons.